Postdoctoral Fellow – Cell fate and gene regulation group (crick)

Job Description

Salary for this Role:

From £43,210 with benefits, subject to skills and experience

Job Title:

Postdoctoral Fellow – Cell fate and gene regulation group

Reports to:

Folkert Van Werven

Closing Date:

31/Aug/2024 23.59 GMT

Job Description:

Postdoctoral Fellow – Cell fate and gene regulation group

Contact term: This is a full time (4 years) position on Crick terms and conditions of employment.

The Research Group

An exciting opportunity to be part of a pioneering biomedical research institute, dedicated to innovation and science. A postdoctoral research post in the laboratory of Folkert van Werven to study Transcription/RNA biology is now available. We are looking for a highly motivated researcher in with a strong affinity for molecular biology and biochemistry, but also candidates with backgrounds in genomics, genetics, and computational biology will be considered. I exact project will be formulated together with the candidate, but is likely on the interface of transcription, noncoding RNAs, and RNA modifications. We use budding yeast and mammalian in vitro cell culture systems as model. The successful applicant will have good communication and organisational skills and a PhD in either Molecular biology/Biochemistry/Genomics/Computational Biology (or be in the final stages of completion).

The Project

Cell differentiation programs depend on dynamic and global changes in gene expression to ensure proper morphologic changes. How regulation of gene expression is controlled during cell fate changes is often not well understood. The laboratory of Folkert van Werven uses budding yeast and mammalian cells to study how RNA expression is regulated when cells change from one state to another. Specifically, we have focused on understanding the roles of transcription, transcript heterogeneity including noncoding RNAs, RNA isoforms, and RNA modifications. The van Werven lab studies basic questions such as: What is the role of noncoding transcription in gene regulation? How do transcript isoforms control gene expression? How do RNA modifications control the fate of transcripts?  The successful candidate will work with members of the research group, but also with various science technology platforms.

Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/research/labs/folkert-van-werven. Research techniques used in the laboratory include: basic techniques of biochemistry, molecular biology, various genomic approaches, genetics, and microscopy. Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators). The ability to work in a team is essential.

Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Noteworthy is that the group of Folkert van Werven will move before the spring of 2027, and the postdoctoral fellow is expected to move with the group.

Key experience and competenciesJOB IS FROM: postdocjobs.oneVIEW

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial. The ideal candidate must have:

• Strong interest in and desire to do basic research in transcription/RNA biology

• Affinity with techniques in molecular biology, biochemistry, bioinformatics, genetics, and genomics

• Apart from working on the main project, a successful candidate should also be able to help others and collaborate with members of the research group

Essential

• PhD in either Molecular biology/Biochemistry/Genomics/Genetics/Computational Biology or in the final stages of PhD submission

• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals

• Evidence of data presentation at scientific meetings

• Ability to work independently as well as interacting within a group

Desirable

• Technical expertise in various molecular biology and biochemical techniques and data analyses

• Experience in using yeast as model including yeast genetics

• Experience in RNA related techniques (such as RNA-seq and CLIP-seq)

• Experience with bioinformatics and genomics

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

• If you are interested in applying for this role, please apply via our website.

• The closing date for applications is 31st of August at 23:59

• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

• If you require a visa to work in the UK we will help support your application should you be successful

Equality, Diversity & Inclusion

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion