Postdoctoral Fellow - Immunology, Kim Lab (roche)

Job Description

We are seeking a highly motivated postdoctoral research fellow to join the Kim lab in the Department of Immunology at Genentech. We are looking for a dynamic and dedicated candidate who has a strong interest in and the essential skills for studying T cells in immune regulation. This postdoctoral fellow will lead the projects that advance our understanding of the cellular and molecular mechanisms of T cell biology in inflammation and autoimmunity, with a main emphasis on tissue specific function of regulatory T cells for reestablishing immune homeostasis. The scientific insights obtained from this project are expected to be published in high impact journals and furthermore provide the basis for therapeutic opportunities for autoimmune disorders such as Multiple Sclerosis. The successful applicant will have an opportunity to work closely with a diverse scientific team including neuroscientists, oncologists, and bioinformaticians.

Qualifications: The successful candidate will be a recent or pending PhD graduate in Immunology, molecular Biology, Cell Biology or related biological science. The candidate will have demonstrated a record of scientific accomplishments including impactful peer-reviewed first author paper(s).

Qualifications

• PhD in Immunology, Molecular Biology, Cell Biology or related biological science

• Enthusiasm in tracking complex biological problems and vigorous scientific logics are desired.

• The successful candidate will have a strong scientific background that could include cellular and molecular Immunology, multi-dimensional flowcytometry and in vivo animal models

• Excellent skills in communication, scientific curiosity and track record in a highly collaborative environment     

Responsibilities

• Mechanisms of restoration of tissue homeostasis in T cell mediated autoimmunity

• Identification of key molecular events of regulatory T cells that control autoinflammation and tissue damage using mouse model of autoimmune disease

Relevant Publications:

1. Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried T, Chan S, Kastner P, Haining WN, Cantor H. (2015) Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science Oct 16. Vol 350 Issue 6258: 334-339.

2. Nakagawa H, Sido JM, Reyes EE, Kiers V, Cantor H*, Kim HJ*. (2016) Instability of Helios-deficient Treg is associated with conversion to a T-effector phenotype and enhanced anti-tumor immunity. PNAS May 31;113(22):6248-53. (*co-senior authors)

3. Goel S, DeCristo M, Watt A, BrinJones H, Sceneay J, Li B, Khan N, Ubellacker J, Xie S, Metger O, Ma C, Hoog J, Ellis M, Ramm S, Krop I, Winer E, Roberts T, Kim HJ*, McAllister S*, Zhao J*. (2017) CDK4/6 inhibition promotes anti-tumor immunity by suppressing DNMT1. Nature 548, 471-475 (*co-senior authors)

4. Yates K, Bi K, Haining WN, Cantor H*, Kim HJ*. (2018) Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells.  PNAS. Feb 27;115(9):2162-2167 (*co-senior authors)

5. Kim HJ, Nakagawa H, Choi JY, Che X, Divris A, Liu Q, Wight A, Zhang H, Saad A, Solhjou Z, Deban C, Azzi J, Cantor H. (2023) A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib-restricted CD8+ regulatory T-cells. J Clin Invest. 2023 Nov 7:e170512

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of California is $64,800 and $120,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  This position also qualifies for the benefits detailed at the link provided below.

For information about the Postdoctoral Program at Genentech, please go to: 

https://www.gene.com/careers/university-and-early-career/postdocs

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.