Postdoctoral Project Research Scientist (Genetic Mechanisms of Disease Lab) (crick)

Job Description

Salary for this Role:

From £41,935 with benefits, subject to skills and experience

Job Title:

Postdoctoral Project Research Scientist (Genetic Mechanisms of Disease Lab)

Reports to:

James Lee [C]

Closing Date:

23.59 GMT

Job Description:

Postdoctoral Project Research Scientist

Job title: Postdoctoral Project Research Scientist (Genetic Mechanisms of Disease Lab)

Reporting to: James Lee

Contact term: This is a full-time, fixed term 2-year position on Crick terms and conditions of employment.

Please note there is no closing date for this vacancy and applicants will be considered on a rolling basis. We encourage you to apply as soon as possible if you are interested in the role.

The Research Group

The Genetic Mechanisms of Disease lab studies how genetic variation affects the normal functioning of the immune system and how this can go wrong in diseases like Crohn’s disease and ulcerative colitis. We use genomics, molecular biology, CRISPR-based methods and dynamic immunological assays to uncover disease mechanisms in primary human immune cells. Our goal is to not only discover the pathways that lead to immune-mediated disease, but to identify opportunities for the next generation of targeted treatments. 

The Project

This role builds on our recent discovery of a transcription factor that functions as a master regulator of inflammatory responses in human macrophages and which is directly linked to multiple inflammatory diseases (https://www.biorxiv.org/content/10.1101/2023.05.05.539522v1). The project will explore the therapeutic potential of targeting this protein by selectively delivering inhibitors to macrophages via antibody-drug conjugates and related methods.

Research techniques used in this project will include primary immune cell isolation and culture, flow cytometry, biochemical activity assays, confocal microscopy, and other chemical biology techniques.

JOB IS FROM: postdocjobs.oneVIEW

Postdoctoral Project Research Scientists are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and help guide PhD students in their research. The ability to work in a team is essential.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Essential

• PhD, or in the final stages of PhD completion, in a relevant biomedical science (including but not limited to: immunology, molecular biology, cell biology, biochemistry) 

• Experience in molecular biology, mammalian cell culture and flow cytometry

• Knowledge of some / all of: human genetics, immunology and biochemistry.

• Experience of working independently, designing experiments and adopting new techniques

• Track record of scientific writing, evidenced by first author publications or submitted manuscripts in refereed journals

• Ability to work independently and as part of a small team

• Excellent organisational and communication skills

Desirable

• Experience in chemical biology / synthesis

• Experience in confocal microscopy

• Experience in bioinformatics (preferably R/Bioconductor)

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

• If you are interested in applying for this role, please apply via our website.

• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

• If you require a visa to work in the UK we will help support your application should you be successful

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion